On all Windows versions, EMET requires .NET Framework 4.
EMET is not supported on Windows versions newer than those listed above. Some people have succeeded in installing version 5.52 to an older Windows version.
Read the user guide. At minimum, I recommend enabling DEP globally and importing the Popular Software.xml configuration file to protect various popular applications. (Besides those, SumatraPDF can also be used with all mitigations.)